Saturday, June 23, 2012

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Friday, June 22, 2012

Euro risks have U.S. businesses readying for the worst

NEW YORK (Reuters) - Three years into the European debt crisis, with the likelihood of the euro's demise still remote, U.S. multinationals are making preparations for a number of grim scenarios that include the worst: the collapse of the euro.

They have been actively looking to lower their hedging costs by taking advantage of the weak euro, while others have been moving money daily to other financial centers to reduce euro zone exposure, consulting firms and banks that hedge for large U.S. corporations say.

"Almost all companies have a committee in some shape or form to prepare to deal with the euro crisis," said Martin Donovan, deputy policy and technical director of the London-based Association of Corporate Treasurers, which advises corporate finance departments.

"The larger companies have been thinking about this for a long time. And it's really gone beyond just a pure housekeeping exercise," Donovan said.

Fireapps, a provider of FX hedging software in Arizona and an adviser to several Fortune 500 companies, did a poll of 800 corporations last month, most of which are U.S.-based. The survey revealed that 88 percent of the companies have or are developing plans to deal with the euro's end.

Minnesota-based medical device maker Medtronic Inc said its cash is actively being transferred out of countries to a central depository to minimize risk.

"We continue to work with every country in Europe to ensure our receivables are being paid. These are normal ongoing procedures to minimize risk, and we believe adequate in the circumstances," said Medtronic spokeswoman Amy von Walter. The company generates about a quarter of its revenue from Europe.

St. Jude Medical , which gets about 25 percent of sales from Europe, said it has cash concentration systems in place in order to minimize the amount of cash held in euros.

U.S. beverage maker PepsiCo has also been doing daily euro sweeps, according to the Financial Times. Calls and e-mails seeking comment were not returned.

"Sweeping" cash is a normal strategy carried out by international companies with bank accounts in different countries. A company takes out cash in each euro-zone country where it has a subsidiary and deposits it nightly in a stable financial center. The company then returns the funds to each country the next day.

Medtronic's and Pepsi's strategy mirrors that of European companies, which have been sweeping euros on a daily basis in case of an overnight currency devaluation.

European companies such as British drugmaker GlaxoSmithKline and Diageo have also been sweeping euros daily for the last several months, the companies said.

Fast-food giant McDonald's said it is closely "monitoring" these strategies, though it is not yet sweeping.

Other U.S. companies have opted to revise the currency denomination of their contracts from euros to dollars.

One U.S. electronic components distributor with annual revenues of $25 billion, for instance, has informed its vendors in the euro zone that it will pay for supplies in dollars instead of euros, according to Wolfgang Koester, president and chief executive officer of Fireapps.

Other U.S. businesses are opting to keep their cash in the United States and those with funds overseas are keeping the funds in liquid and very short-term instruments.

HEDGING FX EXPOSURE

Many companies deriving sales from the euro zone have hedged against the decline in the euro, which is down more than 12 percent over the last three years.

Fireapps' Koester, who advises corporations on hedging, said about 97 percent of U.S. companies have protected against currency volatility, having learned their lesson in 2008. "They are not risking any currency exposure at all," he said.

Heavy equipment maker Caterpillar Inc said it has protected itself against euro weakness, which is necessary as its dealers have reported a sharp slowdown in Europe for a three-month period ended in May.

"We have an even balance for worldwide currency exposure that limits and hedges our risks," said Jim Dugan, Caterpillar's chief corporate spokesperson.

Whitehouse Station, New Jersey-based drugmaker Merck & Co Inc. , which derives about 30 percent of sales from Europe, has an active hedging program in place to protect against the euro's weakness, although company spokesman Ron Rogers said it would be difficult to predict how exchange rates would impact its bottom line.

"At 2011 exchange rates, sales are expected to be at or near 2011 levels. Full-year 2012 sales may be unfavorably affected by foreign exchange, depending on the exact exchange rates," said Rogers.

As more U.S. companies hedged, U.S. banks saw a surge in volume in May as the euro fell below the $1.30-$1.35 range.

Chris Fernandes, senior corporate adviser for Bank of the West in San Ramon, California, said last month's FX hedging volume at his bank was the highest in five to six years.

"Many of our customers with euro payables had assumed an exchange rate of $1.30 per euro on their budgets at the beginning of the year, so now they've locked in FX margins of five to six cents lower (through forward contracts)" than their previous hedges, Fernandes said. That's a good thing for those clients.

Those with euro income, however, are partly hedged because they are hoping the euro will rebound, which would help profits.

"It's just human nature to think that the euro is going to come back," Fernandes said. "These customers are waiting for a rebound in the euro so they can hedge their euro receivables at a higher level."

A major concern among corporate hedgers, Fernandes said, is what would happen to their euro hedges if the euro zone breaks up.

"Ultimately, both sides are obligated to honor the contract," Fernandes said. "The customer is still obligated to deliver the U.S. dollars that they owe us for purchasing a forward contract whether it's for three or six months. And obviously we're obligated to deliver the euro."

(Additional reporting by Lisa Baertlein; Editing by Dan Grebler)

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peeled garlic,21food - How To Make Pickled Garlic?











An innovative addition to any relish tray, pickled garlic can also be used to spice up many sauces and other recipes. It tastes sweeter than raw or cooked garlic. It's relatively easy to make at home using fresh garlic cloves in good condition. Like other relishes, it can be purchased ready-to-eat from many specialty stores. Pickled garlic comes in jars and can be found in a variety of flavors, such as spicy, mild, and habanero, as well as plain.

For those who are particularly adventurous in the kitchen, pickled garlic can also be made at home. The preparation time is minimal, but the soaking of the garlic lengthens the project. Recipes vary depending on the specific tastes of the cook, but most follow the same basic structure.

The garlic should be peeled before it is pickled. Only clean, fresh cloves of garlic should be used to make pickled garlic. Before beginning the pickling process, a cook should examine each clove and discard any that have brown spots or blemishes, are soft and rotted, or are beginning to grow a sprout in the center.

Next, bring six parts white vinegar and one part white sugar to a boil in a large saucepan. Blanching the unpeeled cloves for 30 seconds to 1 minute makes removing the papery skins easier. As the cloves need to be whole or nearly whole when pickled for aesthetic reasons, a cook shouldn't smash the cloves with a knife to remove the peels. Another way to remove the peels is with a vegetable peeler. Other ingredients, such as dill, celery seed, or peppers, can be added during the boiling stage to achieve a different flavor.

Once the mixture has boiled a second time, the cook should take it off the heat and let it sit for a day at room temperature. When the vinegar and peeled garlic mixture has rested for a day, the cook should then pour it into a clean glass jar, cover it with a lid, and store in the refrigerator. Once the jars have been filled, seal them and store them in the refrigerator. In approximately three weeks, you will have your own home-made pickled garlic.

Pickled garlic is not only a delicious treat for garlic lovers. Today, garlic has been proven to contribute to cardiovascular health and to boost the immune system. Historically, garlic has been used to treat arthritis, freckles, and cancer. Like fresh garlic, pickled garlic also has a variety of health benefits.

Ivan Yang?is the freelance writer for e-commerce website in the food industry. 21food.com is just a place for you to look for?any delicious foods! Our 21food.com provide E-commerce business directory for importing & exporting of global food products, especially Chinese food products.

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Meet Harry Potter: Alan Moore's Magical Antichrist

The Boy Who Lived gets a hellacious makeover in the pages of Moore's latest 'League of Extraordinary Gentlemen' comic book.
By Josh Wigler


Daniel Radcliffe as Harry Potter in "Harry Potter and the Half-Blood Prince"
Photo:

"Harry Potter" is not for everyone. Some people do not like fun. Some people do not like magic. Some people do not like fun and magic together. I get it, and I accept it. Harry hate isn't something I'm into, but if that's your position, have a ball. You'll get no killing curses out of me.

But killing curses are flying, it seems, from the wand of Alan Moore.

The critically acclaimed and famously reclusive "Watchmen" writer is drawing a harder line against the boy wizard than even the staunchest "Potter" hater could dream up as the latest installment of Moore's "The League of Extraordinary Gentlemen: Century 2009," out in stores Wednesday (June 20), features Harry Potter as the Antichrist. Well, almost, at least.

There's an undeniable resemblance between Potter and Moore's Antichrist. How startling are the similarities, you ask? Let's count the ways: Moore's character has a notable scar, a mentor named Riddle (the real last name of Potter's lifelong nemesis, Lord Voldemort) and travels to a magic school by way of a magic train hidden in King's Cross station, just like the Boy Who Lived. There is no mention of the words "Harry" or "Potter," but the result is clear: Moore has cast an analogue of J.K. Rowling's globally renowned hero as his very own Antichrist.

Discuss: Did Alan Moore Say Harry Potter Is the Antichrist?

But don't start shipping Howlers off in Moore's direction just yet, "Potter" heads, at least not until you get the full meaning of what the writer is going for here.

In an early review of the new issue of "Century 2009," the Independent's Laura Sneddon analyzes Moore's choice as follows: "The headlines almost write themselves — 'Alan Moore says Harry Potter is the Antichrist!' — yet they miss the point. When the Antichrist is met, overgrown and high on anti-psychotics, raging at the education system that let him down and sounding peculiarly like Harry Enfield's teenage Kevin, he is surely no stand-in for one particular character but of the current obsession for replacing stories with money-generating franchises. Today, film rights are bought before publication, comics are written as storyboards, and teenage celebrities are given memoirs."

"What better representative of modern pop literature than J K Rowling's boy wizard?" Sneddon continues. "Moore's distaste for modern culture is made obvious, in keeping with his stance on the comics publishers he feels betrayed him."

Indeed, it certainly doesn't go unnoticed that "Potter" is a part of the Warner Bros. family, the very same company backing DC Comics' controversial "Before Watchmen" prequel series against Moore's wishes; turnabout is fair play, after all. Moore's choice of Potter as an Antichrist figure isn't necessarily directed at that character or franchise itself, then — instead, he's using the most famous, most recognizable and most relevant face possible to get his anti-franchise point across the table.

"Before Watchmen" Confirmed: Will More Movies Follow?

Is Potter the best option to make such a point? At first, I didn't think so. Haters are going to hate, but the "Potter" books, if not excellently written, are compelling stories with compelling characters who have introduced new readers the entire world over to the fantastic realm of literature. The films, too, aren't just commercial juggernauts, but critically acclaimed ones boasting top-tier talents such as Ralph Fiennes, Alan Rickman, Michael Gambon — the list goes on and on and on. There is strong craftsmanship on display in the "Potter" series on numerous levels. Why target something that's actually good rather than, say, a series that hinges on hollow, vampire-obsessed protagonists? (Hate mail can be sent this way, FYI.)

But in truth, "Potter" doesn't end with the stories. The books are closed, the theaters are empty. (For now.) But there's a whole new wizarding world out there: theme parks, online encyclopedias, unofficial off-Broadway shows and countless other parodies, toys, candy, more. I wouldn't go as far as saying "Potter" replaces story with money-generating greediness, as Moore seems to believe. But there's no denying that "Potter" really is more than just a collection of books and films: It's a lifestyle, not just for fans, but for flesh-and-blood, real-world muggles who keep the Rowling-manufactured train rolling ahead full steam.

If you're looking for an instantly recognizable face to hang your broader anti-franchise sentiments upon, then? Well, I suppose you really don't need to look any further than Hogwarts' finest.

As a "Potter" fan, I don't like seeing Harry used as a symbol of what's wrong in the world today. I'd like to think that there are better examples out there. But if you're looking at what Moore's trying to say here, maybe there really isn't a better example for him to use. Harry isn't just the Boy Who Lived anymore, after all; he is, inarguably, the Boy Who Lived Luxuriously.

How do you feel about Moore's depiction of "Potter" in the latest "League of Extraordinary Gentlemen" comic? Give us your reactions in the comments below, or let me know on Twitter @roundhoward!

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'Breaking Dawn' Trailer: Where Is Renesmee?

New clip gives fans a precious — though tantalizingly brief — glimpse at the newest member of the Cullen family.
By Kara Warner


Kristen Stewart in "Twilight: Breaking Dawn - Part 2"
Photo:

So how about that new "Twilight: Breaking Dawn- Part 2" trailer? Now that we've watched it a few dozen times, we can take a step back to analyze our favorite moments.

First, how great is it to finally get a glimpse of all those other vampires we've been talking about? Finally a first look at Garrett the nomad, played by the divine Lee Pace, as well as Benjamin, Irina and a few others.

But there's one character we wish we saw a little bit more of: Renesmee. Not that we blame Summit and Co. for waiting to reveal more of little Mackenzie Foy-as-Renesmee closer to the film's release, but it would have been nice to see her in action with her parents, interacting with the other Cullens or playing with Jacob.

The moments that we do get to see are very sweet. Fans around the world have been expressing their delight over one scene in particular: when Bella is putting her daughter to bed and tells her "I'll never let anybody hurt you."

"The way vampire Bella looks at Renesmee reminds me of Edwards quote from Twilight... 'You are my life now' :')," one Mackenzie Foy fan tweeted. A fellow fan called the moment "10 seconds of perfection."

In addition to the high praise from fans, that tender moment between mother and daughter has already been given the GIF treatment on several Tumblr blogs.

With all this love for the happy family and that precocious young lady Renesmee, we surely hope we'll get to see more of her in the next trailer.

Check out everything we've got on "The Twilight Saga: Breaking Dawn - Part 2."

For young Hollywood news, fashion and "Twilight" updates around the clock, visit HollywoodCrush.MTV.com.

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Wednesday, June 20, 2012

Structure of RNAi complex now crystal clear

ScienceDaily (June 20, 2012) ? Researchers at Whitehead Institute and Memorial Sloan-Kettering Cancer Center have defined and analyzed the crystal structure of a yeast Argonaute protein bound to RNA. This complex plays a key role in the RNA interference (RNAi) pathway that silences gene expression. Describing the molecular structure of a eukaryotic Argonaute protein has been a goal of the RNAi field for close to a decade.

"You can learn a lot from biochemical experiments, but to more fully understand a protein like Argonaute, it's useful to know where all of the atoms are and which amino acids are playing important roles," says Whitehead Institute Member David Bartel, who is also an MIT professor of biology and a Howard Hughes Medical Institute (HHMI) investigator. "Learning the Argonaute crystal structure is an important step in understanding the RNAi biochemical pathway and will be the basis for many future experiments."

The yeast Argonaute structure is described in the June 21st print issue of Nature.

In humans and most other eukaryotes, the RNAi pathway can reduce cellular protein production by reducing the proteins' RNA templates. By exploiting this pathway, scientists are able to knock down the expression of specific proteins and thereby determine their roles within the cell or organism. The RNAi pathway has also been of considerable interest for the treatment of human disease.

RNAi depends on two proteins, Dicer and Argonaute. Dicer recognizes double-stranded RNA (dsRNA), latches onto it, and chops it into pieces 21-23 nucleotides long. Argonaute recognizes the dsRNA bits, discards one strand, and uses the other as a guide. When a single-stranded RNA matches the guide RNA's sequence, Argonaute cleaves the targeted RNA, thereby preventing it from serving as a template for protein production.

To determine the structure of Argonaute, Bartel and graduate student David Weinberg partnered with Kotaro Nakanishi in Dinshaw Patel's lab at Sloan-Kettering. Although the team expected to solve the structure of Argonaute alone, they were surprised to find that the protein came along with small bits of RNA that were also observed in the structure. The incorporation of these RNAs had switched the protein into an activated state that contained a four-component active site, the identification of which solved a longstanding mystery of what constituted the "missing" fourth component. With the structure of this complex in hand, scientists now have a better understanding for how it works.

"Seeing the crystal structure of a eukaryotic Argonaute for the first time was very exciting -- it's such a large protein with a complicated topology and many moving parts," says Weinberg. "It's a really impressive molecular machine."

This work was supported by National Institutes of Health (NIH), the Human Frontier Science Program, the Japan Society for the Promotion of Science, and the National Science Foundation (NSF).

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The above story is reprinted from materials provided by Whitehead Institute for Biomedical Research, via Newswise. The original article was written by Nicole Giese Rura.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Kotaro Nakanishi, David E. Weinberg, David P. Bartel, Dinshaw J. Patel. Structure of yeast Argonaute with guide RNA. Nature, 2012; DOI: 10.1038/nature11211

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

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